Zofran (ondansetron) is a commonly prescribed medication in Australia used to prevent and treat nausea and vomiting, especially related to chemotherapy, radiotherapy, and surgery. One popular form is the Zofran Zydis wafer, an orally disintegrating tablet that dissolves quickly on the tongue, making it convenient for patients who may have difficulty swallowing.
If you’ve been prescribed Zofran or are curious about its dosing, here’s a clear and up-to-date guide on Zofran doses in Australia, based on official medical sources.
Typical Dosage Range
The dose of Zofran can vary depending on the condition being treated, patient age, and other health factors. Generally, the daily dose ranges between 8 mg and 32 mg, with the goal of using the lowest effective dose.
Common Dosage Guidelines for Adults
- Prevention and treatment of chemotherapy-induced nausea and vomiting:
- A single dose of 8 mg orally before chemotherapy is common.
- For highly emetogenic chemotherapy, doses may be increased or repeated, sometimes up to 24 mg per day, divided into multiple doses.
- Prevention of postoperative nausea and vomiting:
- 4 mg given orally or intravenously just before anesthesia induction.
- Alternatively, 16 mg orally one hour before anesthesia may be used.
- Treatment of established nausea and vomiting:
- 4 mg every 6 to 8 hours as needed, not exceeding 20 mg in 24 hours in some settings.
- Dose adjustments:
- For elderly patients or those with severe liver impairment, the maximum dose is often reduced to 8 mg per day.
How to Take Zofran Zydis Wafers
- Place the wafer on your tongue and allow it to dissolve completely; no water is needed.
- If vomiting occurs within one hour of taking a dose, repeat the dose.
- Follow the dosing schedule prescribed by your doctor carefully.
- Do not take more frequently or in higher doses than directed.
- If you miss a dose and feel nauseous, take it as soon as possible unless it’s near the time for your next dose.
Pediatric Dosage
- Zofran can be used in children over 4 years old for chemotherapy-induced nausea, with dosing based on body surface area (e.g., 5 mg/m² intravenously).
- For postoperative nausea and vomiting in children over 2 years, doses are typically 0.1 mg/kg (up to 4 mg) given intravenously.
What to Do in Case of Overdose
If you suspect an overdose of Zofran, seek immediate medical advice or contact the Poisons Information Centre at 13 11 26 in Australia. Symptoms may include severe headache, dizziness, or irregular heartbeat.
Important Considerations
- Always follow your healthcare provider’s instructions.
- Inform your doctor if you have liver problems, heart conditions, or are elderly as doses may need adjustment.
- Zofran is prescription-only and should not be shared or used without medical advice.
Zofran dosing in Australia is tailored to individual needs, with common adult doses ranging from 4 mg to 16 mg per administration, not exceeding 32 mg daily in most cases. Its convenient wafer form makes it easy to take, especially for those experiencing nausea. Always use Zofran under medical supervision to ensure safe and effective treatment.